TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice.

@article{Frank2008TREM2IU,
  title={TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice.},
  author={Stefanie Th. Frank and Guido J Burbach and Michael Bonin and Michael J. Walter and Wolfgang R. Streit and Ingo Bechmann and Thomas Deller},
  journal={Glia},
  year={2008},
  volume={56 13},
  pages={1438-47}
}
Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-beta protein which attract dense clusters of microglial cells. Here, we analyzed amyloid plaque-associated areas in aged APP23 transgenic mice, an animal model of AD, by combining laser microdissection with microarray analysis and quantitative RT-PCR (qPCR). By comparing gene expression profiles, we found that 538 genes (1.3% of a total of 41,234 analyzed genes) were differentially expressed in plaque-associated… CONTINUE READING

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