TREM2 in Neurodegenerative Diseases

  title={TREM2 in Neurodegenerative Diseases},
  author={T. Jay and Victoria E. von Saucken and G. Landreth},
  journal={Molecular Neurodegeneration},
  • T. Jay, Victoria E. von Saucken, G. Landreth
  • Published 2017
  • Biology, Medicine
  • Molecular Neurodegeneration
  • TREM2 variants have been identified as risk factors for Alzheimer’s disease (AD) and other neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively expressed on immune cells, identification of these variants conclusively demonstrates that the immune response can play an active role in the pathogenesis of NDDs. These TREM2 variants also confer the highest risk for developing Alzheimer’s disease of any risk factor identified in nearly two decades, suggesting that… CONTINUE READING
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    Publications referenced by this paper.
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    No association of TREM1 rs6910730 and TREM2 rs7759295 with Alzheimer disease
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