TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

@inproceedings{Jay2015TREM2DE,
  title={TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models},
  author={Taylor R. Jay and Crystal M Miller and Paul J. Cheng and L C Fudd Graham and Shane M. Bemiller and Margaret L Broihier and Guixiang Xu and Daniel R Margevicius and J. Colleen Karlo and Gregory L. Sousa and Anne C. Cotleur and Oleg Butovsky and Lynn M. Bekris and Susan M. Staugaitis and James Ba Leverenz and Sanjay W Pimplikar and Gary E. Landreth and Gareth R. Howell and Richard M Ransohoff and Bruce T Lamb},
  booktitle={The Journal of experimental medicine},
  year={2015}
}
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2's involvement in neurodegeneration remain to be established. Here, we report that TREM2 is up-regulated on myeloid cells surrounding amyloid deposits in AD mouse models and human AD tissue. TREM2 was detected on CD45(hi)Ly6C(+) myeloid cells, but not on P2RY12(+) parenchymal microglia. In… CONTINUE READING
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