TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

@inproceedings{Leyns2017TREM2DA,
  title={TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy},
  author={Cheryl E G Leyns and Jason Daniel Ulrich and Mary Beth Finn and Floy R. Stewart and Lauren J. Koscal and Javier Remolina Serrano and Grace O Robinson and Elise Anderson and Marco Colonna and David M Holtzman},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017}
}
Variants in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) were recently found to increase the risk for developing Alzheimer's disease (AD). In the brain, TREM2 is predominately expressed on microglia, and its association with AD adds to increasing evidence implicating a role for the innate immune system in AD initiation and progression. Thus far, studies have found TREM2 is protective in the response to amyloid pathology while variants leading to a loss of TREM2… CONTINUE READING
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Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation

  • W Song
  • Alzheimers Dement
  • 2017

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