TREM2 and the neuroimmunology of Alzheimer's disease.

Abstract

Late-onset Alzheimer's disease (AD) is a sporadic disorder with increasing prevalence in aging. The ɛ4 allele of Apolipoprotein E(ApoEɛ4) was the only known major risk factor for late onset AD. Recently, two groups of investigators independently identified variants of the TREM2 gene, encoding triggering receptor expressed on myeloid cells 2 as causing… (More)
DOI: 10.1016/j.bcp.2013.11.021

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