TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.

@article{Cheng2018TREM2activatingAA,
  title={TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function.},
  author={Qingwen Cheng and Jean Danao and Santosh Talreja and Paul H Wen and Jun Yin and Ning Sun and Chi-Ming Li and Danny Chui and David Tran and Samir Koirala and Hang Chen and Ian N. Foltz and Songli Wang and Shilpa Sambashivan},
  journal={The Journal of biological chemistry},
  year={2018},
  volume={293 32},
  pages={
          12620-12633
        }
}
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, supporting the hypothesis that TREM2 loss of function may exacerbate disease progression. However, a complete knockout of the TREM2 gene in different genetic models of neurodegenerative diseases has been reported to result in both protective and… CONTINUE READING