TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

@article{Yuan2016TREM2HI,
  title={TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy},
  author={Peng Yuan and Carlo Condello and C Dirk Keene and Y Claire Wang and Thomas D. Bird and Steven M Paul and Wenjie Luo and Marco Colonna and David Baddeley and Jaime Grutzendler},
  journal={Neuron},
  year={2016},
  volume={92},
  pages={252-264}
}
Haplodeficiency of the microglia gene TREM2 increases risk for late-onset Alzheimer's disease (AD) but the mechanisms remain uncertain. To investigate this, we used high-resolution confocal and super-resolution (STORM) microscopy in AD-like mice and human AD tissue. We found that microglia processes, rich in TREM2, tightly surround early amyloid fibrils and plaques promoting their compaction and insulation. In Trem2- or DAP12-haplodeficient mice and in humans with R47H TREM2 mutations… CONTINUE READING
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