TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells.

Abstract

DCs play a key role in defense against infections and also in preventing inflammatory and autoimmune diseases. The response of DCs to pathogens is tightly regulated by many mechanisms to allow for appropriate, but not pathogenic, responses. We previously showed that DCs with deficiencies for two ITAM-bearing signaling adapters, DAP12 and FcRγ, produce more… (More)
DOI: 10.1002/eji.201141679

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