TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

@article{Kuai2009TREM1EI,
  title={TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.},
  author={Jun Kuai and Brittany S. Gregory and Andrew A. Hill and Debra D. Pittman and Jeffrey L. Feldman and Tom Brown and Brenda A. Carito and Margot O'Toole and Renee Ramsey and Oskar Adolfsson and Kathleen M. Shields and Ken Dower and Jonathan Peter Hall and Yahya A. Kurdi and Jonathan T. Beech and Jagdeep Nanchahal and Marc Feldmann and Brian John Maurice Foxwell and FionulaM. Brennan and David G. Winkler and Lih-Ling Lin},
  journal={Rheumatology},
  year={2009},
  volume={48 11},
  pages={
          1352-8
        }
}
OBJECTIVES To investigate the expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) in the synovium of human RA patients as well as the level of soluble TREM-1 in the plasma of RA patients. METHODS Twenty-four RA synovial samples were analysed by gene expression oligonucleotide microarrays. Expression levels of TREM-1 mRNA in murine CIA paws were determined by quantitative PCR (qPCR). TREM-1 protein expression was detected by immunohistochemistry in five RA… CONTINUE READING

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