TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors.

@article{Weigelt2011TREM1AD,
  title={TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors.},
  author={Karin Weigelt and L{\'i}via A. Carvalho and Roos C. Drexhage and Annemarie J. M. Wijkhuijs and Harm J de Wit and Nico J. M. van Beveren and Tom K Birkenh{\"a}ger and Veerle Bergink and Hemmo A. Drexhage},
  journal={Brain, behavior, and immunity},
  year={2011},
  volume={25 6},
  pages={1162-9}
}
INTRODUCTION Immune activation is a characteristic of schizophrenia (SCZ), bipolar disorder (BD) and unipolar major depressive disorder (MDD). The triggering receptor expressed on myeloid cells 1 (TREM-1), its' adaptor molecule DAP12 and their transcription factor (TF) PU.1 are important key genes in inflammation and expressed in activated monocytes and microglia. AIM To test: (1) if the expressions of TREM-1, DAP12 and PU.1 are increased in monocytes of patients with severe psychiatric… CONTINUE READING
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