TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors.

@article{Arts2013TREM1IS,
  title={TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors.},
  author={Rob J W Arts and Leo A B Joosten and Jos W M van der Meer and Mihai G Netea},
  journal={Journal of leukocyte biology},
  year={2013},
  volume={93 2},
  pages={209-15}
}
TREM-1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM-1. Because of the absence of signaling motifs, TREM-1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM-1 also modulates signaling pathways… CONTINUE READING