TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.

@article{Ord2007TRB3PC,
  title={TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.},
  author={Daima Ord and Kati Meerits and T{\~o}nis Ord},
  journal={Experimental cell research},
  year={2007},
  volume={313 16},
  pages={3556-67}
}
Tribbles homolog 3 (TRB3) is a pseudokinase the level of which is increased in response to various stresses. We and other researchers have previously shown that TRB3 interacts with activating transcription factor 4 (ATF4) and may function as a negative feedback regulator of ATF4. In the present study, we investigate the effect of ATF4 and TRB3 on cell growth and viability, using both the enforced expression and silencing of the genes. HEK293 cells overexpressing ATF4 show retarded growth in the… CONTINUE READING

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