TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1.

@article{Morse2010TRB3IS,
  title={TRB3 is stimulated in diabetic kidneys, regulated by the ER stress marker CHOP, and is a suppressor of podocyte MCP-1.},
  author={Elizabeth Morse and Jana Schroth and Young-Hyun You and Donald P. Pizzo and Shinichi Okada and Satish P Ramachandrarao and Volker Vallon and Kumar Sharma and Robyn Cunard},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 5},
  pages={F965-72}
}
The prevalence of diabetic nephropathy continues to rise, highlighting the importance of investigating and discovering novel treatment strategies. TRB3 is a kinase-like molecule that modifies cellular survival and metabolism and interferes with signal transduction pathways. Herein, we report that TRB3 expression is increased in the kidneys of type 1 and… CONTINUE READING