TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta.

@article{Naiki2007TRB2AM,
  title={TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta.},
  author={Takahiro Naiki and Eiko Saijou and Yuichiro Miyaoka and Keisuke Sekine and Atsushi Miyajima},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 33},
  pages={24075-82}
}
Adipocyte differentiation is regulated by a complex array of extracellular signals, intracellular mediators and transcription factors. Here we describe suppression of adipocyte differentiation by TRBs, mammalian orthologs of Drosophila Tribbles. Whereas all the three TRBs were expressed in 3T3-L1 preadipocytes, TRB2 and TRB3, but not TRB1, were immediately down-regulated by differentiation stimuli. Forced expression of TRB2 and TRB3 inhibited adipocyte differentiation at an early stage. Akt… CONTINUE READING
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