TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes.

@article{Anantharaman2001TRAMAP,
  title={TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes.},
  author={Vivek Anantharaman and Eugene V. Koonin and L. Aravind},
  journal={FEMS microbiology letters},
  year={2001},
  volume={197 2},
  pages={
          215-21
        }
}
A previously undetected conserved domain is identified in two distinct classes of tRNA-modifying enzymes, namely uridine methylases of the TRM2 family and enzymes of the MiaB family that are involved in 2-methylthioadenine formation. This domain, for which the acronym TRAM is proposed after TRM2 and MiaB, is predicted to bind tRNA and deliver the RNA-modifying enzymatic domains to their targets. In addition to the two families of RNA-modifying enzymes, the TRAM domain is present in several… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

From function to structure take the archaeal TRAM.

Environmental microbiology • 2016
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…