TRAIT IMPROVEMENT OF RIBOFLAVIN-PRODUCING Bacillus subtilis BY GENOME SHUFFLING AND METABOLIC FLUX ANALYSIS

@inproceedings{Rui2004TRAITIO,
  title={TRAIT IMPROVEMENT OF RIBOFLAVIN-PRODUCING Bacillus subtilis BY GENOME SHUFFLING AND METABOLIC FLUX ANALYSIS},
  author={Ban Rui},
  year={2004}
}
Traits of riboflavin-producing B.subtilis 24/pMX45 were improved by genome shuffling and DNA recombination.Riboflavin operon of B.subtilis 24 was integrated within chromosome of B.subtilis and was amplified to multi-copies,and B.subtilis RH33/pMX45 were obtained after two rounds of genome shuffling.The strain produced about 100% more riboflavin than the original strain B.subtilis 24/pMX45 in batch culture with 12% glucose as carbon source.In addition, the strain showed some promising traits… CONTINUE READING

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