TRAIP is a master regulator of DNA interstrand cross-link repair

@article{Wu2019TRAIPIA,
  title={TRAIP is a master regulator of DNA interstrand cross-link repair},
  author={R. A. Wu and Daniel R. Semlow and A. Kamimae-Lanning and O. V. Kochenova and Gheorghe Chistol and Michael R G Hodskinson and Ravindra Amunugama and Justin L. Sparks and M. Wang and L. Deng and C. Mimoso and Emily R Low and K. Patel and J. Walter},
  journal={Nature},
  year={2019},
  volume={567},
  pages={267 - 272}
}
Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance. DNA interstrand crosslinks covalently link the two strands of DNA, and thereby block replication and transcription; the cytotoxicity of these crosslinks is exploited for chemotherapy. In Xenopus egg extracts, the collision of replication forks with interstrand crosslinks initiates two distinct repair pathways. NEIL3 glycosylase can… Expand
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References

SHOWING 1-10 OF 59 REFERENCES
DNA interstrand cross-link repair requires replication fork convergence
  • 101
A new varietal of DNA interstrand crosslink repair
  • 1
  • PDF
...
1
2
3
4
5
...