TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage

  title={TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage},
  author={Nam Soo Lee and Hee Jin Chung and Hyoung-June Kim and Seo Yun Lee and Jae-Hoon Ji and Yoojeong Seo and Seung Hun Han and Minji Choi and Miyong Yun and Seok-Geun Lee and Kyungjae Myung and Yonghwan Kim and Ho Chul Kang and HongTae Kim},
  booktitle={Nature communications},
RAP80 localizes to sites of DNA insults to enhance the DNA-damage responses. Here we identify TRAIP/RNF206 as a novel RAP80-interacting protein and find that TRAIP is necessary for translocation of RAP80 to DNA lesions. Depletion of TRAIP results in impaired accumulation of RAP80 and functional downstream partners, including BRCA1, at DNA lesions. Conversely, accumulation of TRAIP is normal in RAP80-depleted cells, implying that TRAIP acts upstream of RAP80 recruitment to DNA lesions. TRAIP… CONTINUE READING

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