TRAIL receptor-2 signals apoptosis through FADD and caspase-8

  title={TRAIL receptor-2 signals apoptosis through FADD and caspase-8},
  author={J J Bodmer and Nils Holler and S{\'e}v{\'e}rine Reynard and Patrizia Vinciguerra and Pascal Schneider and Peter Juo and Joe Blenis and J. -M. Tschopp},
  journal={Nature Cell Biology},
ertain cytokines of the tumour-necrosis factor (TNF) family and their cognate receptors (collectively named death receptors) are potent inducers of programmed cell death (apoptosis). One such protein is the cell-surface receptor Fas, which, upon ligand binding, trimerizes and recruits the adaptor protein FADD through the cytoplasmic death domain of Fas. FADD then binds and activates procaspase-8 (ref. 1). TRAIL, the most recently identified member of the TNF family of death ligands, can induce… CONTINUE READING
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