TRAIL is expressed in the brain cells of Alzheimer's disease patients.

  title={TRAIL is expressed in the brain cells of Alzheimer's disease patients.},
  author={Daniela Letizia Uberti and Giuseppina Cantarella and Fabio F. Facchetti and Alessia Cafici and Giuseppe Grasso and Renato Bernardini and Maurizio Memo},
  volume={15 4},
Tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) is a novel cytokine characterized by selective killing activity against tumour cells. We recently found that beta-amyloid-induced apoptosis in a human neuronal cell line was mediated via induction of TRAIL. Here, we show that TRAIL is specifically expressed in the brain of Alzheimer's disease (AD) patients and completely absent in the brain of non-demented patients. TRAIL-like immunoreactivity was localized in AD affected regions… CONTINUE READING
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