TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions.

@article{Meurette2007TRAILIR,
  title={TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions.},
  author={Olivier Meurette and Am{\'e}lie R{\'e}billard and Laurence Huc and Gwena{\"e}lle Le Moigne and Delphine Merino and Olivier Micheau and Dominique Lagadic-Gossmann and Marie-Th{\'e}r{\^e}se Dimanche-Boitrel},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={218-26}
}
Tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) is a potential anticancer agent that induces apoptosis in cancer cells but not in most normal cells. How tumor physiology, particularly acidic extracellular pH (pH(e)), would modify sensitivity of cancer cells to TRAIL-induced cell death is not known. We have previously shown that cancer cells, resistant to TRAIL-induced apoptosis at physiologic pH(e) (7.4), could be sensitized to TRAIL at acidic pH(e) (6.5). However, at this… CONTINUE READING