TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2

  title={TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2},
  author={U. Vilimanovich and V. Bumbasirevic},
  journal={Cellular and Molecular Life Sciences},
  • U. Vilimanovich, V. Bumbasirevic
  • Published 2008
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • Abstract.TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-sensitive human malignant glioma cells. We show for the first time that TRAIL stimulates cell growth in TRAIL-resistant glioma cells. TRAIL-induced cell growth in resistant cells occurred through increased cell cycle progression as determined by flow cytometry and Western blot analysis of retinoblastoma protein phosphorylation. Western blot analysis of TRAIL-treated resistant cells revealed phosphorylation of ERK1… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Is TRAIL the holy grail of cancer therapy?
    • 125
    • Highly Influenced
    FLIP and the death effector domain family
    • 138
    • PDF
    Towards novel paradigms for cancer therapy
    • 92
    • PDF
    Treatment combinations targeting apoptosis to improve immunotherapy of melanoma
    • 37


    Publications referenced by this paper.
    Inhibition of death receptor signals by cellular FLIP
    • 2,655
    • PDF
    Safety and antitumor activity of recombinant soluble Apo2 ligand.
    • 2,143
    • PDF
    The Receptor for the Cytotoxic Ligand TRAIL
    • 1,725
    TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL
    • 1,114