TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2

@article{Vilimanovich2008TRAILIP,
  title={TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2},
  author={Urosh Vilimanovich and Vladimir Z Bumbasirevic},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={814-826}
}
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-sensitive human malignant glioma cells. We show for the first time that TRAIL stimulates cell growth in TRAIL-resistant glioma cells. TRAIL-induced cell growth in resistant cells occurred through increased cell cycle progression as determined by flow cytometry and Western blot analysis of retinoblastoma protein phosphorylation. Western blot analysis of TRAIL-treated resistant cells revealed phosphorylation of ERK1/2… CONTINUE READING
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