TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.

@article{Takeda2005TRAILII,
  title={TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver.},
  author={Kazuyoshi Takeda and Erika Cretney and Yoshihiro Hayakawa and Tsuyoshi Ota and Hisaya Akiba and Kouetsu Ogasawara and H. Yagita and Katsuyuki Kinoshita and Ko Okumura and Mark J Smyth},
  journal={Blood},
  year={2005},
  volume={105 5},
  pages={2082-9}
}
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a key effector molecule expressed by natural killer (NK) cells and has been shown to prevent tumor initiation, growth, and metastasis. Here we demonstrate that TRAIL is the dominant cytotoxic effector molecule expressed by NK cells in fetal mice. On birth and with age, NK cells develop full functional capacity, including the ability to secrete interferon gamma (IFN-gamma) and interleukin 13 (IL-13) and mediate perforin… CONTINUE READING
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