TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells

@article{Moniri2012TRAILengineeredPM,
  title={TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells},
  author={M R Moniri and X Sun and Jarrett Rayat and Dong Dai and Ziliang Ao and Zhikuan He and C Bruce Verchere and L-J Dai and Garth L. Warnock},
  journal={Cancer Gene Therapy},
  year={2012},
  volume={19},
  pages={652-658}
}
Mesenchymal stem cells (MSCs) have attracted great interest in cancer therapy owing to their tumor-oriented homing capacity and the feasibility of autologous transplantation. Currently, pancreatic cancer patients face a very poor prognosis, primarily due to the lack of therapeutic strategies with an effective degree of specificity. Anticancer gene-engineered MSCs specifically target tumor sites and can produce anticancer agents locally and constantly. This study was performed to characterize… CONTINUE READING
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