TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages.

@article{Kaplan2000TRAILL,
  title={TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages.},
  author={Mariana J Kaplan and Donna D Ray and Ru Ran Mo and Raymond L. Yung and Bruce C. Richardson},
  journal={Journal of immunology},
  year={2000},
  volume={164 6},
  pages={2897-904}
}
The human marrow produces approximately 1010 monocytes daily, and this production must be balanced by a similar rate of destruction. Monocytes/macrophages can undergo apoptosis after activating CD4+ T cells, suggesting one mechanism that may contribute to macrophage homeostasis. Previous reports indicate that Fas-Fas ligand interactions are the principle molecules mediating this response. However, D10, an Iak-restricted cloned Th2 line, will similarly induce apoptosis in Ag-presenting… CONTINUE READING

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