TRAIL/Apo-2L: mechanisms and clinical applications in cancer.

@article{Srivastava2001TRAILApo2LMA,
  title={TRAIL/Apo-2L: mechanisms and clinical applications in cancer.},
  author={Rakesh K Srivastava},
  journal={Neoplasia},
  year={2001},
  volume={3 6},
  pages={535-46}
}
TNF-related apoptosis-inducing ligand (TRAIL/APO-2L) is a member of the TNF family that promotes apoptosis by binding to the transmembrane receptors TRAIL-R1/DR4 and TRAIL-R2/DR5. Its cytotoxic activity is relatively selective to the human tumor cell lines without much effect on the normal cells. Hence, it exerts an antitumor activity without causing toxicity, as apparent by studies with several xenograft models. This review discusses the intracellular mechanisms by which TRAIL induces… CONTINUE READING
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