TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination.

@article{Wang2010TRAF6IA,
  title={TRAF6 is autoinhibited by an intramolecular interaction which is counteracted by trans-ubiquitination.},
  author={Kent Zhi Qiang Wang and Deborah L Galson and Philip E. Auron},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={110 3},
  pages={763-71}
}
The tumor necrosis factor (TNF) receptor associated factor (TRAF) class of intracellular signal transducers is responsible for mediating many of the activation events initiated by TNF receptor (TNFR) and Toll-like/Interleukin-1, -17, and -18 receptor (TIR) families. Investigation of the mechanism by which TRAF6 is activated has demonstrated that two critical domains of the molecule required for activation and downstream signaling are involved in an interaction which renders the molecule… CONTINUE READING
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