TRAF6 is a critical signal transducer in IL-33 signaling pathway.

  title={TRAF6 is a critical signal transducer in IL-33 signaling pathway.},
  author={Megumi Funakoshi-Tago and Kenji Tago and Morisada Hayakawa and Shin-ichi Tominaga and Tomoyuki Ohshio and Yoshiko Sonoda and Tadashi Kasahara},
  journal={Cellular signalling},
  volume={20 9},
IL-33 has been shown to induce Th2 responses by signaling through the IL-1 receptor-related protein, ST2L. However, the signal transduction pathways activated by the ST2L have not been characterized. Here, we found that IL-33-induced monocyte chemoattractant protein (MCP)-1, MCP-3 and IL-6 expression was significantly inhibited in TNF receptor-associated Factor 6 (TRAF6)-deficient MEFs. IL-33 rapidly induced the formation of ST2L complex containing IL-1 receptor-associated kinase (IRAK… CONTINUE READING


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