TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

  title={TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.},
  author={M. A. Lomaga and W. Yeh and I. Sarosi and G. Duncan and C. Furlonger and A. Ho and S. Morony and C. Capparelli and G. Van and S. Kaufman and A. N. van der Heiden and A. Itié and A. Wakeham and W. Khoo and T. Sasaki and Z. Cao and J. Penninger and C. Paige and D. Lacey and C. Dunstan and W. Boyle and D. Goeddel and T. W. Mak},
  journal={Genes & development},
  volume={13 8},
  • M. A. Lomaga, W. Yeh, +20 authors T. W. Mak
  • Published 1999
  • Medicine, Biology
  • Genes & development
  • Bone resorption and remodeling is an intricately controlled, physiological process that requires the function of osteoclasts. The processes governing both the differentiation and activation of osteoclasts involve signals induced by osteoprotegerin ligand (OPGL), a member of tumor necrosis factor (TNF) superfamily, and its cognate receptor RANK. The molecular mechanisms of the intracellular signal transduction remain to be elucidated. Here we report that mice deficient in TNF receptor-associated… CONTINUE READING
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