TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor.

@article{Geetha2012TRAF6AP,
  title={TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor.},
  author={T. L. Geetha and Chen Zheng and Wade C. McGregor and B Douglas White and Mar{\'i}a Teresa D{\'i}az-Meco and Jorge Moscat and Jeganathan Ramesh Babu},
  journal={Neurochemistry international},
  year={2012},
  volume={61 8},
  pages={1289-93}
}
Amyloid β (Aβ) aggregates are the primary component of senile plaques in Alzheimer disease (AD) patient's brain. Aβ is known to bind p75 neurotrophin receptor (p75(NTR)) and mediates Aβ-induced neuronal death. Recently, we showed that NGF leads to p75(NTR) polyubiquitination, which promotes neuronal cell survival. Here, we demonstrate that Aβ stimulation impaired the p75(NTR) polyubiquitination. TRAF6 and p62 are required for polyubiquitination of p75(NTR) on NGF stimulation. Interestingly, we… CONTINUE READING
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