TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology

@article{Wu2003TRAF6AM,
  title={TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology},
  author={H. Wu and J. Arron},
  journal={BioEssays},
  year={2003},
  volume={25}
}
Tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) is a crucial signaling molecule regulating a diverse array of physiological processes, including adaptive immunity, innate immunity, bone metabolism and the development of several tissues including lymph nodes, mammary glands, skin and the central nervous system. It is a member of a group of six closely related TRAF proteins, which serve as adapter molecules, coupling the TNF receptor (TNFR) superfamily to intracellular signaling… Expand
262 Citations
Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer
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Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
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TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3β
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