TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.

@article{Takeshita2005TRAF4AA,
  title={TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.},
  author={Fumihiko Takeshita and Ken J Ishii and Kouji Kobiyama and Yoshitsugu Kojima and Cevayir Coban and Shin Sasaki and Norihisa Ishii and Dennis M Klinman and Kiyoshi Okuda and Shizuo Akira and Koichi Suzuki},
  journal={European journal of immunology},
  year={2005},
  volume={35 8},
  pages={
          2477-85
        }
}
Toll-like receptors (TLR) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase play an essential role in intracellular eradication of engulfed pathogens. Here, we demonstrate the physical and functional association between components of the cytosolic NADPH oxidase and TLR-mediated signaling molecules. Cytosolic components of NADPH oxidase suppressed TLR-mediated NF-kappaB activation as well as IFN-beta promoter activation. We demonstrate that TNF-associated factor (TRAF) 4 associates… CONTINUE READING
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