TRAF3 deficiency promotes metabolic reprogramming in B cells

@inproceedings{Mambetsariev2016TRAF3DP,
  title={TRAF3 deficiency promotes metabolic reprogramming in B cells},
  author={Nurbek Mambetsariev and Wai Wai Lin and Alicia M. Wallis and Laura L. Stunz and Gail A Bishop},
  booktitle={Scientific reports},
  year={2016}
}
The adaptor protein TNF receptor-associated factor 3 (TRAF3) is a critical regulator of B lymphocyte survival. B cell-specific TRAF3 deficiency results in enhanced viability and is associated with development of lymphoma and multiple myeloma. We show that TRAF3 deficiency led to induction of two proteins important for glucose metabolism, Glut1 and Hexokinase 2 (HXK2). This was associated with increased glucose uptake. In the absence of TRAF3, anaerobic glycolysis and oxidative phosphorylation… CONTINUE READING