TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

@article{Vince2009TRAF2MB,
  title={TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-\{kappa\}b and to prevent tnf-induced apoptosis.},
  author={James Edward Vince and Delara Pantaki and Rebecca L Feltham and Peter D Mace and Stephanie M Cordier and Anna C. Schmukle and Angelina J Davidson and Bernard Andrew Callus and Wendy Wei-Lynn Wong and Ian E Gentle and Holly Carter and Erinna F. Lee and Henning Walczak and Catherine L Day and David L. Vaux and John Silke},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 51},
  pages={35906-15}
}
Tumor necrosis factor (TNF) receptor-associated factor-2 (TRAF2) binds to cIAP1 and cIAP2 (cIAP1/2) and recruits them to the cytoplasmic domain of several members of the TNF receptor (TNFR) superfamily, including the TNF-TNFR1 ligand-receptor complex. Here, we define a cIAP1/2-interacting motif (CIM) within the TRAF-N domain of TRAF2, and we use TRAF2 CIM mutants to determine the role of TRAF2 and cIAP1/2 individually, and the TRAF2-cIAP1/2 interaction, in TNFR1-dependent signaling. We show… CONTINUE READING

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icigan State U niersity on M arch 3, 2015 hp://w w w .jb.org/ D

  • M. A. Hughes, N. Harper, M. Butterworth, K. Cain, G. M. Cohen, M. MacFarlane
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