TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice.

@article{Zhang2016TRAF2EO,
  title={TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice.},
  author={Laiqun Zhang and Ken Blackwell and Lauren M. Workman and Katherine Nicole Gibson-Corley and Alicia K. Olivier and Gail A Bishop and Hasem Habelhah},
  journal={Journal of cell science},
  year={2016},
  volume={129 7},
  pages={1455-67}
}
The role of TRAF2 and TRAF5 in TNFα-induced NF-κB activation has become complicated owing to the accumulation of conflicting data. Here, we report that 7-day-old TRAF2-knockout (KO) and TRAF2 TRAF5 double KO (TRAF2/5-DKO) mice exhibit enhanced canonical IκB kinase (IKK) and caspase-8 activation in spleen and liver, and that subsequent knockout of TNFα suppresses the basal activity of caspase-8, but not of IKK. In primary TRAF2 KO and TRAF2/5-DKO cells, TNFα-induced immediate IKK activation is… CONTINUE READING
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