TRAF proteins in CD40 signaling.

  title={TRAF proteins in CD40 signaling.},
  author={Gail A Bishop and Carissa R. Moore and Ping Xie and Laura L. Stunz and Zachary J. Kraus},
  journal={Advances in experimental medicine and biology},
The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions… CONTINUE READING

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