TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3


Receptor-interacting protein kinase 3 (RIP3) is a critical initiator in mediating necroptosis induced by tumor necrosis factor alpha (TNFα) in L929 cells, so knockdown of RIP3 inhibits TNFα-induced L929 cell necroptosis. However, RIP3 knockdown was shown to switch TNFα-induced necroptosis to apoptosis in L929 cells in other studies. Therefore, whether RIP3… (More)
DOI: 10.1038/s41598-017-16390-6


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