TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination.

@article{Berkseth2013TRA1CR,
  title={TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination.},
  author={Matt Berkseth and Kohta Ikegami and Swathi Arur and Jason D. Lieb and David A. Zarkower},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 40},
  pages={16033-8}
}
How sexual regulators translate global sexual fate into appropriate local sexual differentiation events is perhaps the least understood aspect of sexual development. Here we have used ChIP followed by deep sequencing (ChIP-seq) to identify direct targets of the nematode global sexual regulator Transformer 1 (TRA-1), a transcription factor acting at the interface between organism-wide and cell-specific sexual regulation to control all sex-specific somatic differentiation events. We identified… CONTINUE READING
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