TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the amplification of a polyglutamine stretch at the N terminus of the huntingtin protein. N-terminal fragments of the mutant huntingtin (mHtt) aggregate and form intracellular inclusions in brain and peripheral tissues. Aggregates are an important hallmark of the disease… (More)
DOI: 10.1016/j.chembiol.2011.12.020

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Cite this paper

@article{Baldo2012TRFRETbasedDI, title={TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.}, author={Barbara Baldo and Paolo Paganetti and Stephan Grueninger and David Marcellin and Linda S. Kaltenbach and Donald C. Lo and Martin Semmelroth and Andjelija Zivanovic and Doroth{\'e}e Abramowski and Donna Lynn Smith and Gregor P. Lotz and Gillian P Bates and A. Weiss}, journal={Chemistry & biology}, year={2012}, volume={19 2}, pages={264-75} }