TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling.

@article{Ke2015TQIH,
  title={TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling.},
  author={Xiquan Ke and Yan Zhao and Xinlan Lu and Zhe Wang and Yuanyuan Liu and Mudan Ren and Guifang Lu and Dan Zhang and Zhenguo Sun and Zhipeng Xu and Jee Hoon Song and Yulan Cheng and Stephen J. Meltzer and Shuixiang He},
  journal={Oncotarget},
  year={2015},
  volume={6 32},
  pages={
          32610-21
        }
}
Thymoquinone (TQ) has been reported to possess anti-tumor activity in various types of cancer. However, its effects and molecular mechanism of action in hepatocellular carcinoma (HCC) are still not completely understood. We observed that TQ inhibited tumor cell growth in vitro, where treatment with TQ arrested the cell cycle in G1 by upregulating p21 and downregulating cyclinD1 and CDK2 expression; moreover, TQ induced apoptosis by decreasing expression of Bcl-2 and increasing expression of Bax… CONTINUE READING

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