TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556.

@article{Sasaki2001TPU0031AAB,
  title={TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556.},
  author={T. Sasaki and Y. Igarashi and N. Saito and T. Furumai},
  journal={The Journal of antibiotics},
  year={2001},
  volume={54 5},
  pages={
          441-7
        }
}
Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5"-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria… Expand
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