TPN decreases IL-4 and IL-10 mRNA expression in lipopolysaccharide stimulated intestinal lamina propria cells but glutamine supplementation preserves the expression.

@article{Fukatsu2001TPNDI,
  title={TPN decreases IL-4 and IL-10 mRNA expression in lipopolysaccharide stimulated intestinal lamina propria cells but glutamine supplementation preserves the expression.},
  author={Kazuhiko Fukatsu and Kenneth A. Kudsk and Ben L. Zarzaur and Ye Wu and Minna Hanna and R. Chance Dewitt},
  journal={Shock},
  year={2001},
  volume={15 4},
  pages={318-22}
}
Total parenteral nutrition (TPN) decreases intestinal IgA and levels of Th2 cytokines, interleukin (IL)-4, and IL-10 within the supernatants of intestinal homogenates. These cytokines are known to stimulate IgA production in vitro by cells of the gut-associated lymphoid tissue (GALT). Glutamine (GLN) supplementation of TPN normalizes GALT mass and cytokine levels. Because intestinal homogenates contain mucosa which itself is a source of cytokines, it was unclear whether cytokines change within… CONTINUE READING