TPIP: a novel phosphoinositide 3-phosphatase.

  title={TPIP: a novel phosphoinositide 3-phosphatase.},
  author={Steven M Walker and C. Peter Downes and Nicholas R Leslie},
  journal={The Biochemical journal},
  volume={360 Pt 2},
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] 3-phosphatase that plays a critical role in regulating many cellular processes by antagonizing the phosphoinositide 3-kinase signalling pathway. We have identified and characterized two human homologues of PTEN, which differ with respect to their subcellular localization and lipid phosphatase activities. The previously cloned, but… CONTINUE READING


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