TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.

  title={TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.},
  author={Sami Anttila and Merja L Viikki and Kaija Huuhka and Martti J Huuhka and Heini Sisko Annamari Huhtala and Riikka Rontu and Terho Lehtim{\"a}ki and Esa Veli Juhani Leinonen},
  journal={Neuroscience letters},
  volume={464 1},
The association of two tryptophan hydroxylase 2 (TPH2) polymorphisms and treatment response in electroconvulsive therapy (ECT) and the risk of depression was studied. The patient sample consisted of 119 subjects with treatment-resistant major depressive disorder who were treated with ECT. Treatment response was assessed by the Montgomery and Asberg Depression Rating Scale (MADRS) scores. Patients who had <8 scores in post-treatment MADRS were considered remitters; scores >15 indicated non… CONTINUE READING

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