TPH2 gene polymorphisms and bipolar disorder: A meta‐analysis

@article{Gao2016TPH2GP,
  title={TPH2 gene polymorphisms and bipolar disorder: A meta‐analysis},
  author={Jin Gao and Mingrui Jia and D. Qiao and Huimin Qiu and J. Sokolove and Jingxuan Zhang and Z. Pan},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2016},
  volume={171},
  pages={145 - 152}
}
  • Jin Gao, Mingrui Jia, +4 authors Z. Pan
  • Published 2016
  • Biology, Medicine
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Background: Disturbance of the serotonergic system contributes to the etiology of bipolar disorder (BD). Tryptophan hydroxylase‐2 (TPH2) is an important rate‐limiting enzyme in the synthetic pathway for brain serotonin and has been suggested to play a role in BD. Materials and methods: We performed a systematic review and meta‐analysis of all studies to date investigating the association studies between TPH2 and BD published before Aug 2014. All studies were abstracted from PubMed, Embase… Expand
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TLDR
This study supports the involvement of TPH2 in the etiology of BPD, and the functional single-nucleotide polymorphisms identified herein might be the susceptibility loci for BPD. Expand
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