TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients

@article{Wang2010TPH1IA,
  title={TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients},
  author={Hsuan-Chi Wang and Tzung Lieh Yeh and Hui Hua Chang and Po Wu Gean and Mei Hung Chi and Yen Kuang Yang and Ru-band Lu and Po See Chen},
  journal={Psychopharmacology},
  year={2010},
  volume={213},
  pages={773-779}
}
RationaleTryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain.ObjectivesWe aimed to compare the allele frequencies of TPH1 in MDD patients and healthy controls in Taiwan, and also to investigate the association between TPH1 A218C and treatment response to either fluoxetine or… CONTINUE READING

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