TPA-induced inhibition of the expression of differentiative traits in cultured myotubes: dependence on protein synthesis.

@article{Cossu1982TPAinducedIO,
  title={TPA-induced inhibition of the expression of differentiative traits in cultured myotubes: dependence on protein synthesis.},
  author={Giulio Cossu and Maurizio Pacifici and Sergio Adamo and Marina Bouch{\'e} and Mario Molinaro},
  journal={Differentiation; research in biological diversity},
  year={1982},
  volume={21 1},
  pages={62-5}
}
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) dramatically modifies the differentiative program of myotubes, developed in culture from chick embryo skeletal myogenic cells. In fact TPA selectively decreases the expression of differentiative parameters with a lag of 8-10 h from its administration to the cultures. We have tested whether the… CONTINUE READING