TPA-induced differentiation and adhesion of U937 cells: changes in ultrastructure, cytoskeletal organization and expression of cell surface antigens.

@article{Hass1989TPAinducedDA,
  title={TPA-induced differentiation and adhesion of U937 cells: changes in ultrastructure, cytoskeletal organization and expression of cell surface antigens.},
  author={Ralf Hass and Heinrich Bartels and Nicholas Topley and Martin R. Hadam and Lars Detlev K{\"o}hler and Margarete Goppelt-Struebe and Klaus Resch},
  journal={European journal of cell biology},
  year={1989},
  volume={48 2},
  pages={282-93}
}
Incubation of the human promonocytic cell line U937 with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 72 h resulted in differentiation into immature macrophage-like cells and was accompanied by marked morphological and functional changes. U937 cells which normally grow in suspension and show a smooth surface, extended pseudopodia and became adherent to each other and to the surface of the culture vessel. Concomitant with the TPA-induced adherence U937 cells ceased to proliferate. Our results… CONTINUE READING
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