TP53 mutations in familial breast cancer: functional aspects.

  title={TP53 mutations in familial breast cancer: functional aspects.},
  author={Milena Gasco and Isik G. Yulug and Tim Crook},
  journal={Human mutation},
  volume={21 3},
Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia. The occurrence of mutations is somewhat less common in sporadic breast carcinomas than in other cancers, with an overall frequency of about 20%. There is, however, evidence that p53 is mutated at a significantly higher frequency in breast carcinomas arising in carriers of germ-line BRCA1 and BRCA2 mutations. Some of the p53 mutants identified in BRCA1 and BRCA2 mutation carriers are either… CONTINUE READING