TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

  title={TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.},
  author={Laxmi Silwal-Pandit and Hans Kristian Moen Vollan and Suet-Feung Chin and Oscar M. Rueda and Steven McKinney and Tomo Osako and David A. Quigley and Vessela N. Kristensen and Samuel Aparicio and Anne-Lise B\orresen-Dale and Carlos Caldas and Anita Langer\od},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={20 13},
PURPOSE In breast cancer, the TP53 gene is frequently mutated and the mutations have been associated with poor prognosis. The prognostic impact of the different types of TP53 mutations across the different molecular subtypes is still poorly understood. Here, we characterize the spectrum and prognostic significance of TP53 mutations with respect to the PAM50 subtypes and integrative clusters (IC). EXPERIMENTAL DESIGN TP53 mutation status was obtained for 1,420 tumor samples from the METABRIC… CONTINUE READING
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A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients

  • J Alsner, V Jensen, M Kyndi, BV Offersen, P Vu, A-L Børresen-Dale
  • Acta Oncol. 2008;47:600–7. Research. on August
  • 2014
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TP 53 mutation spectrum in breast cancer is subtype speci fi c and has distinct prognostic relevance

  • L Silwal-Pandit, H Vollan, Chin S-F, OM Rueda, S McKinney, T Osako
  • Clin Cancer Res
  • 2014

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